Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.The horizontal blue and orange lines represent median values for S-protein IgG. Among residents with prior COVID-19, levels of S-protein IgG were not statistically significantly different between residents with a positive RT-PCR result for COVID-19 and were either seropositive or seronegative for N-protein IgG compared with those with a negative RT-PCR result for COVID-19 and were seropositive for N-protein IgG ( P = .25). Levels of S-protein IgG that were measured 3 weeks after a single BNT162b2 vaccine dose was administered in January 2021 (1 dot per resident) were significantly lower in residents without prior COVID-19 vs those with prior COVID-19 ( P < .001). Of the 42 residents who had SARS-CoV-2 infection, 36 had a positive RT-PCR result and were seropositive for N-protein IgG, 5 had repeated negative RT-PCR results but were seropositive for N-protein IgG after the outbreak, and 1 had a positive RT-PCR result during the outbreak but was seronegative for N-protein IgG after the outbreak. There were 60 residents who had no prior SARS-CoV-2 infection (repeated negative RT-PCR result for COVID-19 and were seronegative for N-protein IgG after the outbreak) and 42 had SARS-CoV-2 infection (COVID-19). They underwent testing for IgG antibodies against the SARS-CoV-2 nucleocapsid (N) protein 6 weeks after the end of the outbreak. SARS-CoV-2 Antibodies (NCVIGG, NCVIGQ), The qualitative detection of anti-Nucleocapsid IgG (NCVIGG) and the quantitative detection of anti-Spike IgG (NCVIGQ) antibodies.Between March and June 2020, nursing home residents facing a COVID-19 outbreak had repeated reverse transcriptase–polymerase chain reaction (RT-PCR) testing. are able to perform blood draws for testing with a valid provider order. We recommend outside providers arrange to have their patients' blood drawn at their usual clinical draw sites and sent to the lab, preferably after contacting Client Support Services at to facilitate testing.įor patients who do not regularly seek care within UW Medicine, our phlebotomists at the University of Washington Medical Center-Northwest Campus (UWMC-NW) and UWMC-NW Outpatient Medical Center (OPMC) located on Meridian Ave. Ordering: We are pleased to perform serology testing for all patients who have a valid provider order. Results from antibody testing should not be used as the sole basis to diagnose or exclude SARS-CoV-2 infection or to inform infection status. Follow-up testing with a molecular diagnostic should be considered to rule out infection in these individuals. Nonreactive (Negative, <50.0 AU/mL) results do not rule out SARS-CoV-2 infection, particularly in those who have recently been in contact with the virus. Results from antibody testing should not be used as the sole basis to diagnose or exclude SARS-CoV-2 infection or to inform infection status.Ī table of quantitative anti-spike levels for otherwise healthy, recently vaccinated individuals by week of vaccination to aid in interpretation of test results is available in Table 3 in this pre-print. Reactive (Positive, ≥50.0 AU/mL) results may be due to immunization or past or present infection with SARS-CoV-2. The Abbott Architect SARS-CoV-2 IgG II assay, run under an emergency use authorization from the FDA, is quantitative test designed to detect IgG antibodies to the spike protein of SARS-CoV-2 in serum and plasma from individuals with an adaptive immune response to SARS-CoV-2, indicating recent or prior infection.
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